Get my best Week 4 college football against the spread picks, including Miami vs Florida
Expert CFB Week 4 ATS picks feature two home favorites and a home dog getting points
Read below for full Week 4 college football picks against the spread for Sept. 20
After nailing all three picks last time out, I’m back with more CFB ATS picks for college football Week 4. The momentum’s rolling, and there are prime opportunities on Saturday’s slate.
Miami is now laying nearly double digits against Florida, and I still like the Hurricanes to cover. Carson Beck is playing at an elite level, while DJ Lagway can’t stop turning the ball over. That’s a bad combination for the Gators in prime time.
I’m also backing Utah at home against Texas Tech and taking Nebraska with the points against Michigan. Both games have clear edges that the lines don’t fully reflect.
Here’s why these are the best college football teams to back against the spread in Week 4.
College Football Picks Against the Spread Week 4
| Matchup | Spread | Pick |
|---|---|---|
| Florida @ Miami | MIA -8.5 | Miami -8.5 |
| Texas Tech @ Utah | UTAH -3 | Utah -3 |
| Michigan @ Nebraska | MICH -2.5 | Nebraska +2.5 |
Odds as of September 19, 2025. Shop our top recommended college football betting apps for the best Week 4 lines.
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CFB ATS Picks #1: Miami -7.5 vs Florida
I’m starting my Week 4 college football against the spread picks with the Hurricanes rolling at home. Carson Beck’s been absolutely cooking, completing 79.3% of his passes with seven touchdowns and just two picks. That’s elite quarterback play against any level of competition.
Meanwhile, DJ Lagway threw five interceptions last week alone. Five! He’s got six picks through three games and now faces a Miami defense with a +4 turnover margin. The Canes are going to feast on those mistakes.
DJ LAGWAY THROWS HIS 5TH INTERCEPTION OF THE NIGHT 😱 pic.twitter.com/iAlaByoqpM
— SportsCenter (@SportsCenter) September 14, 2025
Miami ranks first nationally in offensive SP+, and they’re outscoring opponents by 34.4 points per game. They beat then-No. 18 USF 49-12 last week. Mark Fletcher ran for 120 yards and two touchdowns in that game, giving the Hurricanes balance to complement Beck’s passing.
Florida’s been bad on the road under Billy Napier. They’re 4-10 away from home in his tenure and winless against ranked opponents on the road. Zero wins in those situations. That stat alone tells you what you need to know.
Hard Rock Stadium has been a fortress for Miami. They’re on a nine-game home winning streak and 6-0 against in-state opponents since last season, winning those games by an average of 34.5 points. The crowd will be electric Saturday night for this rivalry matchup.
Pick: Miami -8.5 (-112 at FanDuel)
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