A.I. College Football Picks for Week 4 – ATS & O/U Predictions from Sportradar Model

SportRadar’s A.I. model posted a solid 5-5 ATS record in Week 3, but dominated totals going 7-3 on over/under picks The model continues targeting unders, picking them in 70% of this week’s marquee matchups Below, see A.I. picks for Week 4’s biggest college football games, including ATS predictions SportRadar’s A.I....

April 16, 2026 • 7:08 AM

SportRadar’s A.I. model posted a solid 5-5 ATS record in Week 3, but dominated totals going 7-3 on over/under picks

The model continues targeting unders, picking them in 70% of this week’s marquee matchups

Below, see A.I. picks for Week 4’s biggest college football games, including ATS predictions

SportRadar’s A.I. model bounced back with a strong totals performance in Week 3, nailing 7 of 10 over/under picks while going .500 on spreads. The model correctly identified low-scoring affairs in games like Florida-LSU and Oregon-Northwestern, both finishing well under their totals.

Week 4 brings massive conference showdowns with playoff implications across the board. From Auburn’s revenge game at Oklahoma to Miami hosting Florida with College GameDay in town, the model has analyzed every angle in the college football odds.

A.I. College Football Picks for Week 4

GameATS PickO/U Pick
Auburn vs Oklahoma AUB +6.5 Under 48.5
Florida vs Miami MIA -7.5 Under 50.5
Texas Tech vs Utah UTAH -3 Over 57.5
Illinois vs Indiana IND -6 Over 52.5
Michigan vs Nebraska NEB +2.5 Under 45.5
Arizona State vs Baylor ASU +2.5 Over 59.5
Tulane vs Ole Miss TUL +13.5 Under 61.5
Arkansas vs Memphis MEM +7.5 Under 62.5
Oregon State vs Oregon ORE -35.5 Over 55.5
South Carolina vs Missouri MIZ -10.5 Over 48.5

A.I. college football picks record to date:

ATS picks: 12-8

O/U picks: 11-9

Picks generated on September 18, 2025. Check out the top college football betting apps ahead of Week 4.

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Model Sticks with College Football Underdog Picks

The A.I. continues its trend of backing underdogs, taking five road dogs this week. This has been the model’s consistent approach through the first three weeks, and it’s paying off again in Week 4.

Auburn getting 6.5 at Oklahoma tops the list, with the model factoring in the Tigers’ dominant rushing attack (242 yards per game) against a Sooners defense that’s allowed just 96.3 on the ground.

Auburn vs Oklahoma Week 4 Roster Comparison♨️ pic.twitter.com/mbp24WMoi5

— PFF College (@PFF_College) September 18, 2025

Nebraska getting points at home against Michigan reflects the Wolverines’ road struggles and quarterback issues. Bryce Underwood threw for just 57.5% last week, while Dylan Raiola’s been accurate with a 76.6% completion rate and zero interceptions.

The model also loves Memphis catching 7.5 against Arkansas. The Tigers’ defense allows just 11 points per game and should slow down Taylen Green, even with his dual-threat ability. This underdog-heavy approach worked last week with wins on Texas A&M, Vanderbilt, West Virginia, Georgia Tech and Arkansas all covering as dogs.

Defensive Battles Dominate AI CFB Predictions

Seven of the 10 games project to go under, with the model particularly confident in Michigan-Nebraska staying under 45.5. Both defenses rank in the top 20 nationally in yards allowed, and neither offense has shown consistency through the air.

Michigan has won the last 4 matchups vs. Nebraska pic.twitter.com/tjhHBlNMLb

— Swanky Wolverine (@swankywolverine) September 16, 2025

Auburn-Oklahoma’s under at 48.5 is expected given Oklahoma’s defense allowing just 6.3 points per game. Jackson Arnold’s return to Norman won’t be a happy homecoming against his former team’s elite defense.

The overs that are projected to hit involve teams with explosive offenses facing vulnerable defenses. Utah-Texas Tech should fly over 57.5 with both teams averaging over 45 points per game.

Key Matchup Analysis

Auburn vs Oklahoma: The model sees value in Auburn despite the line moving toward Oklahoma. The Tigers’ ground game and Oklahoma’s shocking -5 turnover differential create upset potential. If Auburn controls the clock, they can keep this within a touchdown.

Florida vs Miami: Our A.I. backs Miami to cover with Gatros’ QB DJ Lagway struggling. The Hurricanes’ Carson Beck has been elite with a 79.3% completion rate, while Florida has thrown six interceptions in three games (including five last week). The Canes should roll at home.

Illinois vs Indiana: The model likes Indiana’s elite rushing attack (307.7 yards per game) to wear down Illinois. Fernando Mendoza’s 9-to-0 TD-to-INT ratio gives the Hoosiers the quarterback edge in this Big Ten showdown.

A.I. College Football Picks – Results from Week 3

GameATS PickO/U Pick
Georgia vs Tennessee UGA -3.5 LOSS Under 49.5 LOSS
Texas A&M vs Notre Dame TAMU +6.5 WIN Under 49.5 LOSS
Florida vs LSU FLA +7.5 LOSS Under 48.5 WIN
Oregon vs Northwestern ORE -27.5 LOSS Under 48.5 WIN
Vanderbilt vs South Carolina VAN +4 WIN Under 48.5 WIN
Pitt vs West Virginia WVU +7 WIN Under 57.5 WIN
Wisconsin vs Alabama WISC +20.5 LOSS Under 46.5 LOSS
Clemson vs Georgia Tech GT +3 WIN Under 52.5 WIN
Arkansas vs Ole Miss ARK +7 WIN Over 61.5 WIN
South Florida vs Miami USF +17.5 LOSS Over 56.5 WIN

The model nailed some clutch calls last week, including Vanderbilt +4 in their shocking 24-point victory over South Carolina. The closest sweat came in the Oregon-Northwestern game, which landed exactly on 48 points to sneak under by half a point.

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