Week 4 of the College Football season begins Thursday, featuring three matchups between ranked programs
Florida ranks 112th and 91st, respectively in scoring and yards per play
See my favorite Week 4 College Football predictions, and the best early picks to make
I’m hunting value on Monday, scoping out the Week 4 college football betting board, looking for mispriced spreads and totals. Three games immediately jumped off the page to me, two of which feature top-25 programs.
College Football Week 4 Picks
| Pick | Odds | Sportsbook |
|---|---|---|
| Miami -7.5 vs Florida | -110 | DraftKings |
| Tulane +12.5 vs Ole Miss | -112 | DraftKings |
| Wyoming +13.5 vs Colorado | -115 | FanDuel |
Odds as of Sept.15 at DraftKings and FanDuel. Check out the top college football betting apps for Week 4.
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My favorite early Week 4 college football prediction is #4 Miami -7.5 vs Florida. The opening college football Week 4 odds actually had the Canes as 8.5-point chalk, and I’ll gladly take the discount. I’m also targeting Tulane catching 12.5 points versus #13 Ole Miss, while fading Coach Prime and Colorado as massive home favorites.
Florida vs Miami Prediction
Let’s start with the Gators anemic offense. A week after putting up only 16 points versus South Florida, Florida managed just 10 points against LSU. DJ Langway threw 5 interceptions against the Tigers, while the ground game produced only 2.9 yards per carry.
Entering play this week, the Gators sit 112th in scoring and 91st in yards per play. Contrast that with Miami, who are pummeling opponents. The Hurricanes are averaging 38 points, and just whipped a Bulls team by 37 that upset Florida.
Florida Offensive Stats vs FBS Opponents
| Stat | Total |
|---|---|
| Points Per Game | 13.0 |
| Yards Per Game | 360 |
| Yards Per Play | 5.0 |
Heisman trophy odds favorite Carson Beck ranks top-20 in completion percentage and yards per throw, while lead RB Mark Fletcher is averaging 6.5 yards per carry. Miami hung nearly 600 yards on South Florida last week, and are averaging 25 more points per game, and nearly 2 yards more per play than the Gators.
Defensively, they’ve yielded only 15 points total over the last two weeks, and rank top-16 in takeaways and opponent yards per carry. Another strong showing on Saturday will vault them into a top-5 National Championship odds contender.
Miami -7.5 (-110 at DraftKings)
Tulane vs Ole Miss Pick
Next up, give me the Green Wave +12.5. Tulane enters with a perfect 3-0 record, and is the only Group of 5 team with a pair of wins over Power Conference opposition. QB transfer Jake Retzlaff has been a revelation, accounting for 8 TD already. Four of those came on the ground last week in a win over Duke, and the Rebels are very vulnerable against enemy rushing attacks.
Tulane QB Jake Retzlaff WENT OFF against Duke tonight 🔥
🌊 15/23
🌊 245 PASSING YARDS
🌊 111 RUSHING YARDS
🌊 4 RUSHING TOUCHDOWNS#RollWave @GreenWaveFB @jretz11 pic.twitter.com/wBzb7nYwoU
— LIGHT ON COLLEGE SPORTS (@LightOnSports) September 14, 2025
Ole Miss is yielding 5.4 yards per carry early on, and 195 rushing yards per game. They just surrendered 500+ yards of offense in a one-score victory over Arkansas, a result that would have been much different if not for some awful Razorbacks special teams play.
The Rebels are also dealing with an injury to starting QB Austin Simmons, while the Tulane defense is better than expected. The Green Wave are sixth in takeaways, and top-45 in opponent points per play and yards per throw.
Tulane +12.5 (-112 at DraftKings)
Wyoming vs Colorado Best Bet
Finally, I can’t get to the window fast enough to bet against the Buffaloes as massive chalk, even if it means backing Wyoming. Coach Prime can’t seem to make up his mind when it comes to his starting quarterback, and Ryan Staub certainly didn’t impress last week when thrust into the starting role. Staub fumbled two times and was picked off twice in a blowout defeat to Houston.
Coach Prime without Shedeur and Travis pic.twitter.com/ZqX422qWjJ
— eric (@EricMetcalfe) September 13, 2025
Colorado enters play ranked 118th in passing success rate, while their defense has taken a major step back from last season. They check in ranked 110th in defensive success rate, yielding 27+ points in two of three games. The Buffaloes have allowed 6.0 yards per play early on, and even had trouble slowing down the Delaware attack.
The Cowboys on the other hand, were blown out by a very strong Utah team, but outscored their opposition 41-7 in Weeks 1 and 2. Defensively, they grade out 27th in success rate, and are top-17 in opponent points per play and yards per throw.
Wyoming +13.5 (-115 at FanDuel)
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