Missouri vs Auburn Odds, Spread and Picks

The Missouri Tigers visit the Auburn Tigers Saturday, September 24, in SEC play Week 3 NCAAF Record: 1-1: Overall: 1-1 ATS, -0.9 units See below for odds, analysis and our betting prediction It’s a pivot-point clash Saturday when the Missouri Tigers visit the Auburn Tigers, as both schools open up...

April 16, 2026 • 7:43 AM

The Missouri Tigers visit the Auburn Tigers Saturday, September 24, in SEC play

Week 3 NCAAF Record: 1-1: Overall: 1-1 ATS, -0.9 units

See below for odds, analysis and our betting prediction

It’s a pivot-point clash Saturday when the Missouri Tigers visit the Auburn Tigers, as both schools open up SEC play.

Each currently sit 2-1, and the next win could catapult either school into both the conference and bowl-season picture, sending the other team scrambling to get right heading into Week 5 at .500.

It all gets underway Saturday (September 24) from Jordan-Hare Stadium in Auburn at 12pm ET — Missouri’s first-ever visit to the stadium. The game can be seen live on ESPN.

Missouri vs Auburn Odds

Team Spread Moneyline Total
Missouri Tigers +7 (-112) +215 Ov 51 (-114)
Auburn Tigers -7 (-109) -275 Un 51 (-107)

Odds as of September 21st from Barstool Sporstbook. 

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Despite getting blasted in their last game out, the college football odds have the home-side Tigers as 7-point favorites over the visiting Tigers. The game features a total of 51, while Mizzou enters as +215 underdogs to win outright.

Weather should not play a factor in this contest, with 79-degree temperatures expected, sunny skies and some cloudy periods.

Missouri Betting Outlook

Mizzou got itself back in the win column after taking their own beating in Week 2, a 40-12 drubbing at Kansas State.

They bounced back with a 34-17 win over Abilene Christian.

Quarterback Brady Cook had his best game of the season, going 22-for-31 for 297 yards and three TD tosses. He had started the year with just one TD pass and three interceptions.

Dominic Lovett was Cook’s main target, hauling in seven balls for 132 yards and two scores.

While no player crossed 55 yards rushing, the Tigers ran the ball for 190 yards. Eight different players had a touch with at least seven ball-carriers getting at least three totes. Cody Shrader led the way with 10 carries for 54 yards.

Missouri is putting up 204 yards on the ground per game, which ranks 43rd in the nation.

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Auburn Betting Outlook

Auburn was crushed 41-12 in Week 3 by the Penn State Nittany Lions, marking the Tigers’ worst home loss since a 38-0 L to Georgia in 2012.

A pair of freshmen running backs went ran wild at Jordan-Hare, with Nicholas Singleton and Kaytron Allen combining for 19 carries, 176 yards and four rushing TD’s.

The Auburn QB situation was a mess in Week 3, and won’t get any easier going forward.  TJ Finley went 11-for-19 for 152 yards and an interception, before leaving with a shoulder injury that has him already ruled out for Saturday.

Robby Ashford will get his first career start, and he did similar work in relief: 10-for-19 for 144 yards, with a TD and an interception.

In all, Auburn committed four turnovers, while failing to score a TD on four red zone trips, a full 180 from their previous two wins, where they cashed in with majors on every red zone opportunity.

After running wild in two wins over San Jose State and Mercer — combining for 495 yards and eight touchdowns — Auburn’s run game failed to gain traction in Week 3. The Tigers ran for just 119 yards on 36 carries, a paltry 3.3 yards per pop.

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Missouri vs Auburn Pick

Talk about a quirky matchup: Missouri joined the SEC in 2011, and this will only be the second regular-season game between these schools and fourth overall.  They’ve also played in the 2013 SEC Championship and 1973 Sun Bowl. Auburn has won each meeting.

The line on this game originally opened in double-digits, but has settled at the TD mark, following the Finley injury news.

Penn State is a top-30 ranked school in defending the run, giving up just 93 yards per game. Missouri ranks 47th, but they’ve only played one school committed to running, and Kansas State exploited that defense to the tune of 235 yards, a 5.5 yard per carry average and four touchdowns. Auburn should be able to get their ground game going again.

On the other side, Auburn ranks 59th in the NCAA against the run, but like Mizzou, some early season fodder clouds the fact that this defense can be run on with success as well.

With not a lot of head-to-head history, and a pair of teams that don’t see each other much, and both share similar starts to the season, I’d side with the home team to bounce back.

It’s a tough wager against the spread, however, as Auburn will be without their starting pivot, is 0-4 ATS in their last four games, and 0-5 ATS in their last five September games.

The Pick: Missouri +7 (-110); 1 unit to win 0.91 units