New York Mets vs Cleveland Guardians Predictions, Picks & Starting Pitchers (May 21)

The Cleveland Guardians (31-17) host the New York Mets (21-26) after winning the series opener 3-1 on Monday night Adrian Houser (0-3, 7.44 ERA) takes the mound for the Mets against Carlos Carrasco (2-4, 5.16 ERA) of the Guardians See the picks for Tuesday night’s showdown below The Cleveland Guardians...

April 16, 2026 • 10:16 AM

The Cleveland Guardians (31-17) host the New York Mets (21-26) after winning the series opener 3-1 on Monday night

Adrian Houser (0-3, 7.44 ERA) takes the mound for the Mets against Carlos Carrasco (2-4, 5.16 ERA) of the Guardians

See the picks for Tuesday night’s showdown below

The Cleveland Guardians host the New York Mets in interleague action tonight at 6:10 p.m. ET. It’s the first MLB game on the slate for Tuesday, featuring a Cleveland squad that has the second-most wins in the American League, behind only the Yankees.

New York Mets vs Cleveland Guardians Picks

Over 9.0 runs

JD Martinez over 1.5 total bases

You saw the ERAs for the two starting pitchers above. It’s not pretty. Houser has not been good for the Mets since coming over from the Brewers this offseason. However, in May, he’s lowered his ERA nearly a full run, going from an abysmal 8.37 ERA to a slightly less abysmal 7.44. He’s been used out of the bullpen in his last couple of outings, though.

Now that he’s back in the starting lineup, and going against Carrasco, who has an ERA north of 5.00, I expect there to be plenty of runs scored. Thus, I’m taking the over on 9 runs scored. You can find the over at -110 over at bet365.

JD Martinez went 1-for-4 with a double off Ben Lively on Monday night. However, he’s crushed Carlos Carrasco during his career. He is 10-for-27 with 2 doubles, 2 home runs and 9 RBI against him lifetime. That’s solid. I expect the Mets to put Martinez in the middle of the lineup on Tuesday night and let him go to work.

If you can find odds for Martinez over 1.5 total bases at +120 or better, jump on it.

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