MLS Week 4 Odds & Picks: New York vs Columbus, Austin vs Seattle & More

MLS Week 4 kicks off this weekend with 14 matches Last week’s record: 2-1, +0.95 units; Season Record 8-4, +2.99 units Read on for the odds and our best bets for the MLS Week 4 below The MLS season reaches MLS Week 4 this weekend with a heavy slate of...

April 17, 2026 • 5:16 AM

MLS Week 4 kicks off this weekend with 14 matches

Last week’s record: 2-1, +0.95 units; Season Record 8-4, +2.99 units

Read on for the odds and our best bets for the MLS Week 4 below

The MLS season reaches MLS Week 4 this weekend with a heavy slate of 11 matches on Saturday, followed by three on Sunday.

No team has had an easy start to the year as nobody is a perfect 3-0-0. LAFC and RSL lead the West with seven points, while Columbus and Philadelphia sit atop the East, also with seven.

Read on for the odds for MLS Week 4 below, followed by our two top plays for the weekend, as well as a two-team parlay bet.

MLS Week 4 Odds

Matchup Home Draw Away
FC Cincinnati vs Inter Miami +113 +250 +240
NYCFC vs Philadelphia Union -145 +280 +410
Toronto FC vs DC United -135 +255 +190
LA Galaxy vs Orlando City -127 +275 +340
Atlanta United vs CF Montreal -135 +290 +350
Chicago Fire vs Sporting KC -102 +255 +275
Charlotte FC vs New England Revolution +240 +255 +110
Minnesota United vs San Jose Earthquakes -160 +300 +440
Houston Dynamo vs Colorado Rapids +145 +235 +190
FC Dallas vs Portland Timbers +107 +250 +255
Real Salt Lake vs Nashville SC +155 +205 +200
New York Red Bulls vs Columbus Crew -125 +280 +330
Austin FC vs Seattle Sounders -121 +240 +230
LAFC vs Vancouver Whitecaps -255 +390 +675

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When looking at the above odds be sure to consider that four teams played midweek in the CONCACAF Champions League when deciding on the pros and cons of betting on these teams.

New York City FC advanced on away goals against CSD Comunicaciones on Tuesday. On Wednesday New England was eliminated on penalties versus Pumas while Montreal drew with Cruz Azul to be eliminated over the two legs. Thursday, the Sounders drew 1-1 with Leon but advanced 4-1 on aggregate.

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