Pegula vs Sabalenka Prediction, Picks & Betting Lines

World #1 Aryna Sabalenka is a -320 moneyline favorite over #4 Jessica Pegula in Thursday’s US Open Semifinal Sabalenka is 7-2 all-time versus Pegula, including a win in last year’s US Open Final See the Pegula vs Sabalenka prediction, picks and betting lines, below Stop if you’ve heard this matchup...

April 17, 2026 • 6:30 AM

World #1 Aryna Sabalenka is a -320 moneyline favorite over #4 Jessica Pegula in Thursday’s US Open Semifinal

Sabalenka is 7-2 all-time versus Pegula, including a win in last year’s US Open Final

See the Pegula vs Sabalenka prediction, picks and betting lines, below

Stop if you’ve heard this matchup before: Aryna Sabalenka vs Jessica Pegula in a high-stakes US Open showdown. The pair met in last year’s final with Sabalenka emerging victorious, and online sportsbooks expect a repeat performance in Thursday’s semifinal.

The action is scheduled for 7:00 pm ET on Arthur Ashe, with ESPN providing the broadcast coverage.

Pegula vs Sabalenka Betting Lines

MarketPegulaSabalenka
Moneyline +250 at bet365 -320 at FanDuel
Game Spread +4.5 (-110) at bet365 -4.5 (+104) at FanDuel
Total Games O 21.5 (-120) at bet365 U 21.5 (-115) at DraftKings

The most favorable odds for Sabalenka’s moneyline are -320 at FanDuel, while you can also bet her to cover the 4.5-game spread there at +104 odds. Pegula’s best odds to pull off the upset are +250 at bet365, which also has the best odds for her to cover the game spread. As for the total games, the consensus number is 21.5 around the industry, with bet365 and DraftKings offering the best odds on the over and under, respectively.

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