Welcome to the Pickswise NFL Week 1 betting guide! We have arrived at the beginning of the regular season, which kicked off on Thursday night with a big upset as the Detroit Lions paid a visit to the Kansas City Chiefs and took down the defending Super Bowl champions.
Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the opening slate of the NFL regular season.
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NFL Week 1 picks
NFL picks against the spread and total for EVERY Week 1 game
NFL best bets
NFL parlays
Pickswise Nation’s Call It: The People’s Parlay – (+2450 odds)
Pickswise Nation’s Call It: Hottest Public Teams for Week 1
NFL Week 1 expert betting picks and predictions
Pickswise experts’ best bets
NFL Week 1 mega parlay (+1046 odds!)
Millionaire maker 15-team parlay
Dallas Cowboys vs New York Giants SNF Same Game Parlay
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NFL Week 1 prop bets
Week 1 touchdown scorer best bets
Sunday player prop best bets – from Prop Holliday
Sunday Night Football prop bets – from Prop Holliday
Cowboys vs Giants SNF touchdown scorer picks
Monday Night Football prop bets – from Prop Holliday
NFL Week 1 big-game predictions
Bengals vs Browns predictions
49ers vs Steelers predictions
Raiders vs Broncos predictions
Dolphins vs Chargers predictions
Eagles vs Patriots predictions
Cowboys vs Giants predictions
Bills vs Jets predictions
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